Symbol
Name
ID

Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat)
MGI:3039785

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Drooling

Torticollis

Brain atrophy

EEG abnormality

Language impairment

Autistic behavior

Intellectual disability

Intellectual disability, moderate

Epileptic encephalopathy

Developmental regression

Global developmental delay

Motor delay

Seizure

Bilateral tonic-clonic seizure

Myoclonic absence seizure

Disease(s) Associated with SYNGAP1

autosomal dominant intellectual developmental disorder 5

Mouse Phenotypes

nervous system phenotype

increased susceptibility to pharmacologically induced seizures

audiogenic seizures

increased neuron apoptosis

decreased brain size

abnormal hippocampus pyramidal cell morphology

abnormal neuron morphology

abnormal dendrite morphology

abnormal dendritic spine morphology

impaired synaptic plasticity

abnormal CNS synaptic transmission

abnormal excitatory postsynaptic potential

abnormal glutamate-mediated receptor currents

enhanced AMPA-mediated synaptic currents

reduced long-term potentiation

abnormal miniature excitatory postsynaptic currents

increased miniature excitatory postsynaptic current amplitude

increased miniature excitatory postsynaptic current frequency

abnormal miniature inhibitory postsynaptic currents

increased miniature inhibitory postsynaptic current amplitude

increased miniature inhibitory postsynaptic current frequency

decreased prepulse inhibition

Availability

Mouse Genotype

Syngap1^tm1.1Mabk/Syngap1^tm1.1Mabk

Syngap1^tm1Rlh/Syngap1^tm1Rlh

Syngap1^tm1Grnt/Syngap1⁺

Syngap1^tm1Rlh/Syngap1⁺

Syngap1^tm1.1Mabk/Syngap1^tm1.2Mabk
Tg(Camk2a-cre)2834Lusc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23